A surface-induced asymmetric program promotes tissue colonization by Pseudomonas aeruginosa. Bacterial quorum-sensing systems and their role in intestinal bacteria-host crosstalk. A Streptococcus quorum sensing system enables suppression of innate immunity. Bacterial quorum sensing: its role in virulence and possibilities for its control. Exposing such binary states opens up new ways to control mucosal infections by a major human pathogen. We also demonstrate that the HecE pathway represents a druggable target to effectively counter P. The fraction of HecE + cells is tuned by different stress factors and determines the balance between biofilm formation and long-range cell dispersal of surface-grown communities. HecE inhibits the phosphodiesterase BifA and stimulates the diguanylate cyclase WspR to increase c-di-GMP second messenger levels and promote surface colonization in a subpopulation of cells low-level HecE-expressing cells disperse. aeruginosa growth and dispersal on surfaces. Here we identified a stochastic genetic switch, hecR–hecE, which is expressed bimodally and generates functionally distinct bacterial subpopulations to balance P. Urs Jenal ORCID: /0000-0002-1637-3376 1Įfficient colonization of mucosal surfaces is essential for opportunistic pathogens like Pseudomonas aeruginosa, but how bacteria collectively and individually adapt to optimize adherence, virulence and dispersal is largely unclear.A genetic switch controls Pseudomonas aeruginosa surface colonization
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